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Test Code LAB12637 Metanephrines, Fractionated - 24 Hour Urine

Department

SEND OUTS

Reference Lab Test Number

UMET

Collection Requirements

24 hour urine collection: The bladder must be emptied at the time the collection is to begin, and this urine is discarded. Thereafter all urine must be collected until the end of the scheduled time.

Preferred method of collection for 24 hour collection: Collect urine with 6N HCl at start of collection to maintain pH between 1 and 3. Refrigerate urine during collection (critical). Mix the collection well before removing aliquot. Record total volume on test request and on container label. Send refrigerated 25 mL aliquot (10 mL minimum).

See Additional Information

Refer To

Warde Medical Laboratory

Primary Collection Container

24 HR Urine container

Transport

Urine refrigerated

Preferred Transport Temperature

Refrigerated

Processing

Send 25 mL acidified in a screw-capped plastic urine container. Record total volume on test requisition and specimen label.

Stability

With preservative:

Ambient: 9 days

Refrigerated: 9 days

Frozen: 30 days

Preservative must be added before sample is submitted for testing.

Minimum Testing Volume

10 mL

Reference Range

Metanephrine:

Age Range 0-3 months 6-37 mcg/day 4-6 months 6-42 mcg/day 7-9 months 12-41 mcg/day 10-12 months 9-101 mcg/day 1-2 years 7-52 mcg/day 3-6 years 11-99 mcg/day 7-10 years 54-138 mcg/day 11-16 years 39-242 mcg/day ≥17 yrs 52-341 mcg/day

Normetanephrine:

Age Range 0-3 months 47-156 mcg/day 4-6 months 31-111 mcg/day 7-9 months 42-109 mcg/day 10-12 months 23-103 mcg/day 1-2 years 32-118 mcg/day 3-6 years 50-111 mcg/day 7-10 years 47-176 mcg/day 11-16 years 53-290 mcg/day ≥17 years 88-444 mcg/day

Total Metanephrines:

Age Range 0-3 months 53-193 mcg/day 4-6 months 37-153 mcg/day 7-9 months 54-150 mcg/day 10-12 months 32-204 mcg/day 1-2 years 39-170 mcg/day 3-6 years 61-210 mcg/day 7-10 years 101-314 mcg/day 11-16 years 92-532 mcg/day ≥17 years 140-785 mcg/day

Creatinine:

Male: 1.0-2.0 g/24 hrs Female: 0.8-1.8 g/24 hrs

Methodology

High Performance Liquid Chromatography

Performed

Monday-Friday

Reported

6 Days

CPT Codes

83835, 82570

Unacceptable Conditions

Samples with pH <1.

Additional Information

NOTE: Medications that may interfere with metanephrine include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), methyldopa (Aldomet), MAO inhibitors, nose drops, propafenone (Rythmol), trycyclic antidepressants, and vasodilators.