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HelpTest Code MISC1WARDE4207SP Canrenone (Spironolactone Metabolite, Aldactone®) - Serum/Plasma
Department
SEND OUTS
Reference Lab Test Number
4207SP
Refer To
Primary Collection Container
Red (No Gel)
Alternate Collection Container
Lavender 4 mL (K3EDTA)
Transport
Serum or plasma refrigerated
Preferred Transport Temperature
Refrigerated
Processing
Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines.
Stability
Ambient: 2 days
Refrigerated: 1 month
Frozen (-20 °C): 12 months
Minimum Testing Volume
0.4 mL
Reference Range
5.0 ng/mL
Spironolactone is rapidly metabolized to canrenone in plasma, a pharmacologically active metabolite with an average half-life of 20 h.
After single doses of spironolactone in fasting subjects, reported peak plasma canrenone concentrations were:
Spironolactone Dose – Peak Canrenone Concentration
200 mg – 225 ng/mL
100 mg – 98 ng/mL
50 mg – 60 ng/mL
Methodology
High Performance Liquid Chromatography/TandemMass Spectrometry (LC-MS/MS)
Performed
Tuesday
Reported
2-3 days
CPT Codes
80375
Unacceptable Conditions
Received Room Temperature. Polymer gel separation tube (SST or PST).
Additional Information
Testing forwarded to NMS Labs by Warde Medical Laboratory.