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Test Code MISC1WARDEPGD2 Prostaglandin D2 (PG D2)

Department

SEND OUTS

Reference Lab Test Number

PGD2

Collection Requirements

Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.

For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Primary Collection Container

Lavender 6 mL (K3EDTA)

Alternate Collection Container

Red (No Gel)

Transport

Frozen

Preferred Transport Temperature

Frozen

Processing

3 ml serum or EDTA plasma should be collected and separated as soon as possible. Freeze specimen immediately after separation. Minimum specimen size is 1 ml.

Minimum Testing Volume

1.0 mL

Reference Range

35 – 115 pg/ml

Methodology

Prostaglandin D2 is measured by radioimmunoassay following extraction of specimens.

CPT Codes

-84150

Additional Information

Testing forwarded to ISI by Warde Medical Laboratory.

Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.