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Test Code MISC2MAYO6MAMM 6-Monoacetylmorphine (6-MAM), Confirmation, Meconium

Reporting Name

6-MAM Confirmation, M

Useful For

Detection of in utero drug exposure up to 5 months before birth

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Meconium


Advisory Information


For chain-of-custody testing, order MAMMX / 6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium.



Specimen Required


Supplies: Stool container, Small (Random), 4 oz (T288)

Container/Tube: Stool container (T288)

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions:

1. Collect entire random meconium specimen.

2. Send specimen frozen. When refrigerated, a significant percentage of 6-MAM will convert to morphine in less than 24 hours.


Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Meconium Frozen 14 days

Reference Values

Negative

Positives are reported with a quantitative LC-MS/MS result.

Cutoff concentration:

6-MAM by LC-MS/MS: 5 ng/g

Day(s) and Time(s) Performed

Monday through Sunday; Varies

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80356

G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
6MAMM 6-MAM Confirmation, M 29345-6

 

Result ID Test Result Name Result LOINC Value
31874 6-Monoacetylmorphine 29345-6
31875 Interpretation 69050-3

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.