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Test Code MISC2MAYOALLM B-Cell Lymphoblastic Leukemia (B-ALL) Monitoring, Minimal Residual Disease (MRD) Detection, Bone Marrow

Useful For

Aids in monitoring a previously confirmed diagnosis of B-cell lymphoblastic leukemia

Additional Tests

Test ID Reporting Name Available Separately Always Performed
FIRST Flow Cytometry, Cell Surface, First No, (Bill Only) Yes
ADD1 Flow Cytometry, Cell Surface, Addl No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, flow cytometry interpretation, 2 to 8 markers will always be performed at an additional charge.


See Acute Leukemias of Ambiguous Lineage Testing Algorithm in Special Instructions

Reporting Name

B-ALL Monitoring, MRD Detection, BM

Specimen Type

Bone Marrow

Additional Testing Requirements

If cytogenetic tests are also desired an additional specimen should be submitted. It is important that the specimen be obtained, processed, and transported according to instructions for the other required test.

Shipping Instructions

Specimens must be received within 72 hours.

Necessary Information


Specimen Required


Preferred: Yellow top (ACD solution A or B)
Acceptable: EDTA, Sodium heparin
Specimen Volume: 3 mL

Slides: Include 5- to 10-unstained bone marrow aspirate smears, if possible.
Collection Instructions:
1. Submission of bilateral specimens is not required.
2. Label specimen appropriately (bone marrow).

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Bone Marrow Ambient

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Reference Values

An interpretive report will be provided.

This test will be processed as a laboratory consultation. An interpretation of the immunophenotypic findings and correlation with the morphologic features will be provided by a hematopathologist for every case.

Day(s) and Time(s) Performed

Specimens are processed and reported Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker
88185 x 7-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each)
88187-Flow cytometry interpretation, 2 to 8 markers

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ALLM B-ALL Monitoring, MRD Detection, BM In Process


Result ID Test Result Name Result LOINC Value
CK085 ALLM Result No LOINC Needed
CK088 Final Diagnosis 22637-3
CK089 Special Studies 30954-2
CK090 Microscopic Description 22635-7

Method Name


Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FCINT Flow Cytometry Interp, 2-8 Markers No, (Bill Only) No


If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.