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HelpTest Code MISC2MAYOPROG Progesterone Receptor (PR) Immunostain, Technical Component Only
Ordering Guidance
This test includes only technical performance of the stain (no pathologist interpretation is performed).
For qualitative IHC testing of estrogen receptor alpha protein for diagnostic purposes without interpretation, order ESTR / Estrogen Receptor Immunostain, Technical Component Only
For prognostic or predictive IHC detection of both estrogen and progesterone receptor proteins for primary breast or non-breast specimens with interpretation, order ERPR / Estrogen/Progesterone Receptor, Semi-Quantitative Immunohistochemistry, Manual.
For interpretation and diagnosis of submitted pathology specimens with appropriate additional stains and other ancillary testing, order PATHC / Pathology Consultation.
Additional material may be needed if alternative testing is requested. See the specific specimen requirements for any alternative requested testing.
Shipping Instructions
Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Specimen Required
Specimen Type: Tissue
Supplies: Immunostain Technical Only Envelope (T693)
Container/Tube: Immunostain Technical Only Envelope
Submit:
-Formalin-fixed, paraffin-embedded tissue block
OR
-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Secondary ID
70542Useful For
Qualitative detection of progesterone receptor protein in a diagnostic setting
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IHTOI | IHC Initial, Tech Only | No | No |
| IHTOA | IHC Additional, Tech Only | No | No |
Method Name
Immunohistochemistry (IHC)
Reporting Name
Progesterone Rec IHC, Tech OnlySpecimen Type
TECHONLYSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| TECHONLY | Ambient (preferred) | |
| Refrigerated | ||
Reject Due To
| Wet/frozen tissue Cytology smears Nonformalin fixed tissue Nonparaffin embedded tissue Noncharged slides ProbeOn slides Snowcoat slides |
Reject |
Clinical Information
Progesterone receptor is a hormone receptor localized within the nucleus. It is highly expressed in the epithelial cells of the breast and endometrium, and smooth muscle cells of the uterus. This antibody is used along with that for estrogen receptor to assess hormonal responsiveness in breast cancer.
Interpretation
This test does not include pathologist interpretation, only technical performance of the stain.
The positive and negative controls are verified as showing appropriate immunoreactivity.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Method Description
Immunohistochemistry on sections of paraffin-embedded tissue.(Unpublished Mayo method)
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
88342-TC, Primary
88341-TC, If additional IHC
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PROG | Progesterone Rec IHC, Tech Only | Order only;no result |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 70854 | Progesterone Rec IHC, Tech Only | Bill only; no result |
Forms
If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.