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Test Code MISC2MAYOPYRC Pyruvate, Spinal Fluid

Reporting Name

Pyruvic Acid, CSF

Useful For

Investigating possible disorders of mitochondrial metabolism, when used in conjunction with cerebrospinal fluid lactate, collected at the same time, to determine the lactate-to-pyruvate (L:P) ratio


Evaluating patients with neurologic dysfunction and normal blood L:P ratios

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Additional Testing Requirements

This test does not calculate the lactate:pyruvate ratio. To obtain this information, both this test and LABF / Lactate, Body Fluid must be ordered. The ratio can be calculated from the results obtained from these tests.

Specimen Required

Container/Tube: Sterile vial

Specimen Volume: 0.6 mL

Collection Instructions: Send specimen from vial 2.

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Frozen (preferred) 7 days
  Ambient  7 days
  Refrigerated  7 days

Reference Values

0.06-0.19 mmol/L

Day(s) and Time(s) Performed

Monday, Thursday; Varies

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PYRC Pyruvic Acid, CSF 14122-6


Result ID Test Result Name Result LOINC Value
83356 Pyruvic Acid, CSF 14122-6

Reject Due To

Gross hemolysis Reject

Method Name

Spectrophotometry (SP)


1. Biochemical Genetics Patient Information (T602) in Special Instructions.

2. If not ordering electronically, complete, print, and send an Inborn Errors of Metabolism Test Request (T798) with the specimen.

Testing Algorithm

See Epilepsy: Unexplained Refractory and/or Familial Testing Algorithm in Special Instruction.