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Test Code MISC2MAYOTERT TERT Promoter Analysis, Tumor


Advisory Information


At least 20% tumor is required for this assay. The amount of tissue needed is dependent on a variety of preanalytical factors (eg, cellularity, ischemic time, fixation). In general, the minimum specimen adequacy for this test is approximately a 6 mm(2) area of tissue (can be over multiple slides from 1 tissue block) or 5,000 total cells (5,000 total nucleated cells if using cytology slides).



Necessary Information


Pathology report must accompany specimen in order for testing to be performed.



Specimen Required


Preferred

Specimen Type: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block

Acceptable

Slides: 1 stained and 10 unstained slides

Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained slides (nonbaked, charged slides preferred) with 5-micron thick sections of the tumor tissue.

 

Specimen Type: Cytology slide (Direct smears or ThinPrep)

Slides: 1-2 slides

Collection Instructions: Submit 1-2 slides stained and coverslipped with at least 5,000 total nucleated cells

Additional Information: Cytology slides will not be returned.


Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

Secondary ID

65415

Useful For

Assisting in central nervous system tumor classification

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge.

Method Name

Polymerase Chain Reaction (PCR)-Based Next-Generation Sequencing

Reporting Name

TERT Promoter Analysis, Tumor

Specimen Type

Varies

Specimen Minimum Volume

Formalin-fixed, paraffin-embedded tissue block (preferred) or 1 slide stained with hematoxylin and eosin and 10 unstained, non-baked slides with 5-microns thick sections of the tumor tissue with at least 6 mm(2) area of tissue (can be over multiple slides from one tissue block) and at least 20% tumor cells

Specimen Stability Information

Specimen Type Temperature Time
Varies Ambient (preferred)
  Frozen 
  Refrigerated 

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Specimens that have been decalcified (all methods); specimens that have not been formalin-fixed, paraffin-embedded; bone marrow in EDTA

Reference Values

An interpretative report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81345

88381

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TERT TERT Promoter Analysis, Tumor In Process

 

Result ID Test Result Name Result LOINC Value
92389 Result Summary 50397-9
92390 Result 82939-0
92391 Interpretation 69047-9
92392 Additional Information 48767-8
92393 Specimen 31208-2
92394 Source 31208-2
92395 Tissue ID 80398-1
92396 Released By 18771-6