Sign in →

Test Code MTRBM MatePair, Targeted Rearrangements, Hematologic, Varies

Secondary ID


Useful For

Second-tier testing in hematologic specimens when previous cytogenetic or FISH testing have detected an acquired chromosome abnormality of unknown significance


Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected by other methods such as conventional chromosome and FISH studies


Providing important diagnostic, prognostic, and therapeutic information critical to proper patient management

Method Name

Mate-Pair Whole Genome Sequencing

Reporting Name

MatePair, Targeted, Hematologic

Specimen Type


Shipping Instructions

Advise Express Mail or equivalent if not on courier service.

Necessary Information

1. Previous cytogenetic or FISH testing is required in order to perform this test. If previous testing was performed at another institution, submit a copy of the results or the Mate Pair Hematology/Oncology Patient Information (see Special Instructions). Testing will be canceled if sufficient information regarding the patient's known chromosome abnormality is not made available.

2. A reason for referral must be provided for testing to be performed.

3. A pathology report should accompany the specimen. If this information is not available at the time of order, submit as soon as possible for appropriateness of testing and to aid in interpretation of results.

Specimen Required

Submit only 1 of the following specimens:


Specimen Type: Bone marrow

Container/Tube: Green top (sodium heparin)

Specimen Volume: 1-2 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send specimens in original tubes.


Specimen Type: Whole blood

Container/Tube: Green top (sodium heparin)

Specimen Volume: 7-10 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimens in original tubes.

Specimen Minimum Volume

Blood: 2 mL
Bone Marrow: 1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Samples processed Monday through Friday. Results reported Monday through Friday, 8 a.m.-5 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MTRBM MatePair, Targeted, Hematologic In Process


Result ID Test Result Name Result LOINC Value
48013 Result Summary 50397-9
48325 Result 48001-2
48014 Nomenclature 62356-1
48015 Interpretation 69965-2
CG987 Reason for Referral 42349-1
CG984 Specimen 31208-2
48018 Source 31208-2
48019 Method 49549-9
48020 Additional Information 48767-8
48022 Released By 18771-6


1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Mate Pair Hematology/Oncology Patient Information in Special Instructions

3. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.

Testing Algorithm

See B-Lymphoblastic Leukemia/Lymphoma Algorithm in Special Instructions